The Beverly Hillbillies
All in the Family
Sanford and Son
The Drew Carey Show
My name is Earl
Two and a Half Men
The Grim Adventures of Billy and Mandy
Did I miss any? I know Seinfeld and Friends were popular, but they just never grabbed me.
Update: Am I the only one who considers The Grim Adventures of Billy and Mandy as biting and insightful a social commentary as is House?